Duoliv 10mg Tablet | View Uses, Dosage, Interaction, Price | ePharma
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Duoliv 10mg Tablet

Generic: Obeticholic Acid

Type: Tablet

Pack Size: 10pcs

Obeticholic Acid is a medicine used to treat primary biliary cirrhosis (a condition that impairs your liver's ability to function properly and causes a build-up of a fluid called bile within the liver).


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Discount Price: ৳ 517
MRP: ৳ 550 6% Off

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✅ Description:

Duoliv 10mg Tablet is a medication that falls under the category of Farnesoid X-receptor agonists. It is primarily used to treat a condition known as primary biliary cirrhosis (or cholangitis), which is an autoimmune disease characterized by damage to the bile ducts in the liver. This damage results in the accumulation of bile in the liver, leading to liver damage over time.

Duoliv 10mg Tablet contains the active ingredient 'Obeticholic acid,' which plays a crucial role in improving liver function through several mechanisms:

  1. Reducing the production and buildup of bile in the liver.
  2. Increasing the removal of bile from the liver.
  3. Reducing inflammation within the liver.

By addressing these aspects, Duoliv 10mg Tablet helps in the management and treatment of primary biliary cirrhosis.

Here are some important points to keep in mind when using Duoliv 10mg Tablet:

  • It should be taken as prescribed by your healthcare provider.
  • Common side effects may include stomach pain, tiredness, dizziness, constipation, and palpitations. Many of these side effects are usually mild and transient, but if they persist or worsen, it's advisable to consult your doctor.
  • If you are pregnant or breastfeeding, you should consult your doctor before using Duoliv 10mg Tablet.
  • This medication is not recommended for use in children and adolescents.
  • Duoliv 10mg Tablet may cause dizziness, so it's important to exercise caution when driving or operating machinery.
  • The interaction between alcohol and Duoliv 10mg Tablet is not well-documented, so if you have concerns or questions about alcohol use while taking this medication, it's best to discuss them with your doctor.
  • It's essential to keep your doctor informed about your overall health condition and any other medications you may be taking to monitor for potential interactions or side effects.

Safety Advices


Alcohol
UNSAFE

There is limited information on the interaction of Duoliv 10mg Tablet with alcohol. Please discuss with your doctor regarding the consumption of alcohol with Duoliv 10mg Tablet.


Pregnancy
UNSAFE
  • Caution is advised for pregnant individuals. Limited information is available regarding the use of Duoliv 10mg Tablet during pregnancy.
  • It's crucial to consult your doctor if you are pregnant. Your healthcare provider will weigh the potential benefits and risks before deciding whether Duoliv 10mg Tablet is suitable for you during pregnancy.

Breastfeeding
SAFE
  • If you are breastfeeding, you should consult your doctor. The decision to use Duoliv 10mg Tablet while breastfeeding will be made by your healthcare provider.
  • Your doctor will consider various factors and assess whether the benefits of treatment outweigh any potential risks for breastfeeding mothers and their infants.

Driving
CAUTION
  • Duoliv 10mg Tablet is generally considered safe for driving when taken as prescribed.
  • However, it's essential to be cautious. If you experience dizziness while using this medication, it is advised to refrain from driving or operating heavy machinery to ensure your safety and the safety of others.

Kidney
CONSULT YOUR DOCTOR
  • If you have kidney impairment or any concerns related to your kidney health, you should consult your doctor.
  • Your healthcare provider will assess whether Duoliv 10mg Tablet is suitable for you based on your kidney function and overall health.

Liver
CAUTION
  • Caution is recommended if you have a liver impairment or if you have any concerns related to your liver.
  • Dose adjustments may be necessary for individuals with liver impairment. It is important to consult your doctor in such cases to determine the appropriate dosage and monitor your liver function during treatment.
  • Additionally, inform your doctor if you have or have had liver cirrhosis, as this may impact the use of Duoliv 10mg Tablet.

Similar Products

✔️ Uses:

Primary biliary cirrhosis

✔️ How to take Duoliv 10mg Tablet work?

Take Duoliv 10mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition

✔️ Side Effects of Duoliv 10mg Tablet
  • Stomach pain
  • Constipation
  • Dizziness
  • Tiredness
  • Fast or irregular heartbeat
  • Dry skin
  • Swelling of hands and feet
  • Fever
✔️ Quick Suggestions:
  • Refilling Your Prescription: If you have any questions or concerns about refilling your prescription, do not hesitate to ask your pharmacist. They can provide guidance and ensure that you continue to receive your medication as needed.
  • Keep a Medication List: Maintaining a written list of all the prescription and nonprescription (over-the-counter) medicines you are taking, along with any vitamins, minerals, or dietary supplements, is important. This list should include the names of the medications, dosages, and the reasons for taking them.
  • Share Your Medication List: You should carry this list with you when you visit your healthcare provider and if you are admitted to a hospital. It provides valuable information to your healthcare team and can help avoid potential drug interactions or complications. In emergencies, having this list readily available can be life-saving.
✔️ Indications:

Primary biliary cirrhosis (PBC) is a chronic liver condition characterized by the progressive destruction of the bile ducts in the liver. This leads to the accumulation of bile within the liver, causing inflammation and scarring. Over time, the scarring can impair liver function and lead to cirrhosis.

Obeticholic Acid is a medication used to treat PBC. It belongs to a class of drugs called Farnesoid X receptor agonists. It works by reducing the production of bile in the liver and increasing the removal of bile from the liver. This helps to manage the symptoms of PBC and slow down the progression of the disease.

✔️ Pharmacology

Obeticholic Acid activates the farnesoid X receptor (FXR), a nuclear receptor found in the liver and gut. FXR plays a critical role in bile acid, inflammatory, fibrotic, and metabolic pathways. FXR activation reduces bile acid concentrations within hepatocytes by limiting de novo cholesterol production and increasing bile acid transport out of hepatocytes. These mechanisms reduce hepatic bile acid exposure and increase choleresis.

✔️ Dosage & Administration
  • Take Duoliv 10mg Tablet as a whole with sufficient water.
  • Always take this medicine exactly as prescribed by your doctor.
  • Do not consume more than the prescribed dose.
  • Do not discontinue the medicine on your own without consulting your doctor.
  • If you suspect that you have taken an overdose of Obeticholic Acid, you should seek immediate medical attention. Overdose symptoms may include itching, swelling of the belly due to fluid buildup, and jaundice. It's essential to contact your doctor or visit the nearest hospital for evaluation and appropriate medical care.
  • If you happen to miss a dose of Obeticholic Acid, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects and complications. Always follow your healthcare provider's instructions regarding medication dosing and timing.
✔️ Interaction

Obeticholic Acid can interact differently from person to person, and it's crucial to discuss all potential interactions with your doctor before starting any new medication. Some specific interactions to consider include:

  • Alcohol: The interaction with alcohol is not well-known, so it's advisable to consult your doctor regarding alcohol consumption while taking Obeticholic Acid.
  • Other Medications: Obeticholic Acid may interact with several medications, such as Clozapine, Aminophylline, and Ketoconazole. It's essential to inform your doctor about all the medications you are taking to ensure there are no adverse interactions.
  • Disease Interactions: Information about interactions with specific diseases is not available. Your doctor will assess your medical history to determine if Obeticholic Acid is suitable for your condition.
  • Food Interactions: There is no specific information available regarding food interactions with Obeticholic Acid.
  • Lab Interactions: Details about interactions with laboratory tests are not available.
✔️ Contraindications

Obeticholic Acid should not be used by patients with known hypersensitivity to the medicine or any of its components, as well as those with total biliary obstruction.

✔️ Pregnancy & Lactation

There is insufficient human data to establish the drug-associated risk of Obeticholic Acid consumption during pregnancy. Additionally, there is no information on its presence in human milk, its effects on breastfed infants, or its impact on milk production.

✔️ Precautions & Warnings
  • Allergies: Inform them if you are allergic to Obeticholic Acid, any other medications, or any of the ingredients in Obeticholic Acid tablets. You can ask your pharmacist for a list of the ingredients if needed.
  • Current Medications: Provide a detailed list of all the prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are currently taking or plan to take. It's crucial to mention specific medications like caffeine, cyclosporine, theophylline, rosuvastatin, tizanidine, and warfarin, as your doctor may need to adjust your medication doses or monitor you for potential side effects.
  • Cholesterol-Lowering Resins: If you are taking cholestyramine, colestipol, or colesevelam, you should take them at least 4 hours before or after taking Obeticholic Acid.
  • Bile Duct Obstruction: Inform your doctor if you have or have ever had bile duct obstruction, as you may be advised not to take Obeticholic Acid.
  • Pregnancy and Breastfeeding: Let your doctor know if you are pregnant, planning to become pregnant, or currently breastfeeding. If you become pregnant while taking Obeticholic Acid, contact your doctor.
✔️ Storage Conditions

Keep at 15°C to 30°C in a dry, light-protected location. Keep out of children's reach.

Frequently Asked Questions (FAQ)

The exact cause of Primary Biliary Cholangitis (PBC) is unknown, but it is believed to be related to immune system dysfunction. While PBC is not classified as a hereditary disease caused by a specific gene or genetic defect passed from parent to child, there is evidence of a familial connection. PBC tends to occur more frequently among siblings and in families where one member has been affected.

You should inform your doctor about all medicines, including non-prescription medicines, herbals, and supplements that you are taking. Also, inform your doctor if you are pregnant or breastfeeding.

Duoliv 10mg Tablet can be used for the treatment of a liver disease called primary biliary cirrhosis in adults. Your doctor will prescribe you this medicine if it is suitable for you. Do not take this medicine on your own.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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