Obeticholic Acid is a medicine used to treat primary biliary cirrhosis (a condition that impairs your liver's ability to function properly and causes a build-up of a fluid called bile within the liver).
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Duoliv 10mg Tablet is a medication that falls under the category of Farnesoid X-receptor agonists. It is primarily used to treat a condition known as primary biliary cirrhosis (or cholangitis), which is an autoimmune disease characterized by damage to the bile ducts in the liver. This damage results in the accumulation of bile in the liver, leading to liver damage over time.
Duoliv 10mg Tablet contains the active ingredient 'Obeticholic acid,' which plays a crucial role in improving liver function through several mechanisms:
By addressing these aspects, Duoliv 10mg Tablet helps in the management and treatment of primary biliary cirrhosis.
Here are some important points to keep in mind when using Duoliv 10mg Tablet:
There is limited information on the interaction of Duoliv 10mg Tablet with alcohol. Please discuss with your doctor regarding the consumption of alcohol with Duoliv 10mg Tablet.
Primary biliary cirrhosis
Take Duoliv 10mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition
Primary biliary cirrhosis (PBC) is a chronic liver condition characterized by the progressive destruction of the bile ducts in the liver. This leads to the accumulation of bile within the liver, causing inflammation and scarring. Over time, the scarring can impair liver function and lead to cirrhosis.
Obeticholic Acid is a medication used to treat PBC. It belongs to a class of drugs called Farnesoid X receptor agonists. It works by reducing the production of bile in the liver and increasing the removal of bile from the liver. This helps to manage the symptoms of PBC and slow down the progression of the disease.
Obeticholic Acid activates the farnesoid X receptor (FXR), a nuclear receptor found in the liver and gut. FXR plays a critical role in bile acid, inflammatory, fibrotic, and metabolic pathways. FXR activation reduces bile acid concentrations within hepatocytes by limiting de novo cholesterol production and increasing bile acid transport out of hepatocytes. These mechanisms reduce hepatic bile acid exposure and increase choleresis.
Obeticholic Acid can interact differently from person to person, and it's crucial to discuss all potential interactions with your doctor before starting any new medication. Some specific interactions to consider include:
Obeticholic Acid should not be used by patients with known hypersensitivity to the medicine or any of its components, as well as those with total biliary obstruction.
There is insufficient human data to establish the drug-associated risk of Obeticholic Acid consumption during pregnancy. Additionally, there is no information on its presence in human milk, its effects on breastfed infants, or its impact on milk production.
Keep at 15°C to 30°C in a dry, light-protected location. Keep out of children's reach.
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