Duoliv 10mg Tablet

Uses:

Primary biliary cirrhosis

How to take Duoliv 10mg Tablet work?

Take Duoliv 10mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition

Side Effects of Duoliv 10mg Tablet

• Stomach pain
• Constipation
• Dizziness
• Tiredness
• Fast or irregular heartbeat
• Dry skin
• Swelling of hands and feet
• Fever

Quick Suggestions:

• Refilling Your Prescription: If you have any questions or concerns about refilling your prescription, do not hesitate to ask your pharmacist. They can provide guidance and ensure that you continue to receive your medication as needed.
• Keep a Medication List: Maintaining a written list of all the prescription and nonprescription (over-the-counter) medicines you are taking, along with any vitamins, minerals, or dietary supplements, is important. This list should include the names of the medications, dosages, and the reasons for taking them.
• Share Your Medication List: You should carry this list with you when you visit your healthcare provider and if you are admitted to a hospital. It provides valuable information to your healthcare team and can help avoid potential drug interactions or complications. In emergencies, having this list readily available can be life-saving.

Indications:

Primary biliary cirrhosis (PBC) is a chronic liver condition characterized by the progressive destruction of the bile ducts in the liver. This leads to the accumulation of bile within the liver, causing inflammation and scarring. Over time, the scarring can impair liver function and lead to cirrhosis.

Obeticholic Acid is a medication used to treat PBC. It belongs to a class of drugs called Farnesoid X receptor agonists. It works by reducing the production of bile in the liver and increasing the removal of bile from the liver. This helps to manage the symptoms of PBC and slow down the progression of the disease.

Pharmacology

Obeticholic Acid activates the farnesoid X receptor (FXR), a nuclear receptor found in the liver and gut. FXR plays a critical role in bile acid, inflammatory, fibrotic, and metabolic pathways. FXR activation reduces bile acid concentrations within hepatocytes by limiting de novo cholesterol production and increasing bile acid transport out of hepatocytes. These mechanisms reduce hepatic bile acid exposure and increase choleresis.

Dosage & Administration

• Take Duoliv 10mg Tablet as a whole with sufficient water.
• Always take this medicine exactly as prescribed by your doctor.
• Do not consume more than the prescribed dose.
• Do not discontinue the medicine on your own without consulting your doctor.
• If you suspect that you have taken an overdose of Obeticholic Acid, you should seek immediate medical attention. Overdose symptoms may include itching, swelling of the belly due to fluid buildup, and jaundice. It's essential to contact your doctor or visit the nearest hospital for evaluation and appropriate medical care.
• If you happen to miss a dose of Obeticholic Acid, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects and complications. Always follow your healthcare provider's instructions regarding medication dosing and timing.

Interaction

Obeticholic Acid can interact differently from person to person, and it's crucial to discuss all potential interactions with your doctor before starting any new medication. Some specific interactions to consider include:

• Alcohol: The interaction with alcohol is not well-known, so it's advisable to consult your doctor regarding alcohol consumption while taking Obeticholic Acid.
• Other Medications: Obeticholic Acid may interact with several medications, such as Clozapine, Aminophylline, and Ketoconazole. It's essential to inform your doctor about all the medications you are taking to ensure there are no adverse interactions.
• Disease Interactions: Information about interactions with specific diseases is not available. Your doctor will assess your medical history to determine if Obeticholic Acid is suitable for your condition.
• Food Interactions: There is no specific information available regarding food interactions with Obeticholic Acid.
• Lab Interactions: Details about interactions with laboratory tests are not available.

Contraindications

Obeticholic Acid should not be used by patients with known hypersensitivity to the medicine or any of its components, as well as those with total biliary obstruction.

Pregnancy & Lactation

There is insufficient human data to establish the drug-associated risk of Obeticholic Acid consumption during pregnancy. Additionally, there is no information on its presence in human milk, its effects on breastfed infants, or its impact on milk production.

Precautions & Warnings

• Allergies: Inform them if you are allergic to Obeticholic Acid, any other medications, or any of the ingredients in Obeticholic Acid tablets. You can ask your pharmacist for a list of the ingredients if needed.
• Current Medications: Provide a detailed list of all the prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are currently taking or plan to take. It's crucial to mention specific medications like caffeine, cyclosporine, theophylline, rosuvastatin, tizanidine, and warfarin, as your doctor may need to adjust your medication doses or monitor you for potential side effects.
• Cholesterol-Lowering Resins: If you are taking cholestyramine, colestipol, or colesevelam, you should take them at least 4 hours before or after taking Obeticholic Acid.
• Bile Duct Obstruction: Inform your doctor if you have or have ever had bile duct obstruction, as you may be advised not to take Obeticholic Acid.
• Pregnancy and Breastfeeding: Let your doctor know if you are pregnant, planning to become pregnant, or currently breastfeeding. If you become pregnant while taking Obeticholic Acid, contact your doctor.

Storage Conditions

Keep at 15°C to 30°C in a dry, light-protected location. Keep out of children's reach.